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six week old female balb c  (Charles River Laboratories)

 
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    Charles River Laboratories six week old female balb c
    Conjugation of R848 to H1ssF-Cys nanoparticles (A) Representative image of H1ssF-Cys mutant. (B and C) Size (B) and PDI (C) analysis of H1ssF (WT and Cys mutant) using DLS. (D) Schematic for conjugation of R848 to <t>H1ssF-Cys.</t> <t>BALB/c</t> mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. (E) BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. The dotted line indicates the limit of detection for the assay. TT was defined as the highest dilution with an OD 450 greater than three times the assay background. Lines represent the mean ± SEM. (F) Negatively stained TEM images of the conjugated H1ssF-R848. The scale bar lengths are as follows: 50 nm (A and F, left), 10 nm (F, right). Not significant p ≥ 0.05 (not indicated on graph), ∗∗ p ≤ 0.01, ∗∗∗∗ p ≤ 0.0001.
    Six Week Old Female Balb C, supplied by Charles River Laboratories, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/six+week+old+female+balb+c/pmc13198238-76-0-4?v=Charles+River+Laboratories
    Average 86 stars, based on 1 article reviews
    six week old female balb c - by Bioz Stars, 2026-08
    86/100 stars

    Images

    1) Product Images from "A dual-adjuvanted HA stem nanoparticle vaccine elicits a multifunctional antibody response that is associated with protection in newborn monkeys"

    Article Title: A dual-adjuvanted HA stem nanoparticle vaccine elicits a multifunctional antibody response that is associated with protection in newborn monkeys

    Journal: Cell Reports Medicine

    doi: 10.1016/j.xcrm.2026.102746

    Conjugation of R848 to H1ssF-Cys nanoparticles (A) Representative image of H1ssF-Cys mutant. (B and C) Size (B) and PDI (C) analysis of H1ssF (WT and Cys mutant) using DLS. (D) Schematic for conjugation of R848 to H1ssF-Cys. BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. (E) BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. The dotted line indicates the limit of detection for the assay. TT was defined as the highest dilution with an OD 450 greater than three times the assay background. Lines represent the mean ± SEM. (F) Negatively stained TEM images of the conjugated H1ssF-R848. The scale bar lengths are as follows: 50 nm (A and F, left), 10 nm (F, right). Not significant p ≥ 0.05 (not indicated on graph), ∗∗ p ≤ 0.01, ∗∗∗∗ p ≤ 0.0001.
    Figure Legend Snippet: Conjugation of R848 to H1ssF-Cys nanoparticles (A) Representative image of H1ssF-Cys mutant. (B and C) Size (B) and PDI (C) analysis of H1ssF (WT and Cys mutant) using DLS. (D) Schematic for conjugation of R848 to H1ssF-Cys. BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. (E) BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. The dotted line indicates the limit of detection for the assay. TT was defined as the highest dilution with an OD 450 greater than three times the assay background. Lines represent the mean ± SEM. (F) Negatively stained TEM images of the conjugated H1ssF-R848. The scale bar lengths are as follows: 50 nm (A and F, left), 10 nm (F, right). Not significant p ≥ 0.05 (not indicated on graph), ∗∗ p ≤ 0.01, ∗∗∗∗ p ≤ 0.0001.

    Techniques Used: Conjugation Assay, Mutagenesis, Staining



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    Conjugation of R848 to H1ssF-Cys nanoparticles (A) Representative image of H1ssF-Cys mutant. (B and C) Size (B) and PDI (C) analysis of H1ssF (WT and Cys mutant) using DLS. (D) Schematic for conjugation of R848 to <t>H1ssF-Cys.</t> <t>BALB/c</t> mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. (E) BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. The dotted line indicates the limit of detection for the assay. TT was defined as the highest dilution with an OD 450 greater than three times the assay background. Lines represent the mean ± SEM. (F) Negatively stained TEM images of the conjugated H1ssF-R848. The scale bar lengths are as follows: 50 nm (A and F, left), 10 nm (F, right). Not significant p ≥ 0.05 (not indicated on graph), ∗∗ p ≤ 0.01, ∗∗∗∗ p ≤ 0.0001.
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    Conjugation of R848 to H1ssF-Cys nanoparticles (A) Representative image of H1ssF-Cys mutant. (B and C) Size (B) and PDI (C) analysis of H1ssF (WT and Cys mutant) using DLS. (D) Schematic for conjugation of R848 to <t>H1ssF-Cys.</t> <t>BALB/c</t> mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. (E) BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. The dotted line indicates the limit of detection for the assay. TT was defined as the highest dilution with an OD 450 greater than three times the assay background. Lines represent the mean ± SEM. (F) Negatively stained TEM images of the conjugated H1ssF-R848. The scale bar lengths are as follows: 50 nm (A and F, left), 10 nm (F, right). Not significant p ≥ 0.05 (not indicated on graph), ∗∗ p ≤ 0.01, ∗∗∗∗ p ≤ 0.0001.
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    Image Search Results


    Conjugation of R848 to H1ssF-Cys nanoparticles (A) Representative image of H1ssF-Cys mutant. (B and C) Size (B) and PDI (C) analysis of H1ssF (WT and Cys mutant) using DLS. (D) Schematic for conjugation of R848 to H1ssF-Cys. BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. (E) BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. The dotted line indicates the limit of detection for the assay. TT was defined as the highest dilution with an OD 450 greater than three times the assay background. Lines represent the mean ± SEM. (F) Negatively stained TEM images of the conjugated H1ssF-R848. The scale bar lengths are as follows: 50 nm (A and F, left), 10 nm (F, right). Not significant p ≥ 0.05 (not indicated on graph), ∗∗ p ≤ 0.01, ∗∗∗∗ p ≤ 0.0001.

    Journal: Cell Reports Medicine

    Article Title: A dual-adjuvanted HA stem nanoparticle vaccine elicits a multifunctional antibody response that is associated with protection in newborn monkeys

    doi: 10.1016/j.xcrm.2026.102746

    Figure Lengend Snippet: Conjugation of R848 to H1ssF-Cys nanoparticles (A) Representative image of H1ssF-Cys mutant. (B and C) Size (B) and PDI (C) analysis of H1ssF (WT and Cys mutant) using DLS. (D) Schematic for conjugation of R848 to H1ssF-Cys. BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. (E) BALB/c mice ( n = 3–12 across 3–4 experiments depending on the vaccine tested) were vaccinated and NC99 stem-specific Abs were quantified 14 days p.v. The dotted line indicates the limit of detection for the assay. TT was defined as the highest dilution with an OD 450 greater than three times the assay background. Lines represent the mean ± SEM. (F) Negatively stained TEM images of the conjugated H1ssF-R848. The scale bar lengths are as follows: 50 nm (A and F, left), 10 nm (F, right). Not significant p ≥ 0.05 (not indicated on graph), ∗∗ p ≤ 0.01, ∗∗∗∗ p ≤ 0.0001.

    Article Snippet: Six-week-old female BALB/c , Charles River Laboratories , Cat# 028.

    Techniques: Conjugation Assay, Mutagenesis, Staining